Before you can delete a publication, you must first:
Delete all of the subscriptions that subscribe to that publication
Suspend the primary database connection
Delete all of the primary articles in that publication
For more information, see:
To delete an ASE Replicator publication:
Select the primary Adaptive Server in the left pane.
Open the ASE Replicator folder under the primary Adaptive Server container.
Select a primary connection in the ASE Replicator folder.
In the right pane, right-click the icon of the publication you want to delete.
Select Delete.
Click Yes in the Question dialog box.